One of the longstanding questions in neuroscience is to understand how memories are stored and retrieved. In order to test this hypothesis, I developed computational tools in collaboration with Profs. Karl Deisseroth, Priya Rajasethupathy and colleagues at Stanford University. We found that the information is stored as a small world network. We also found the existence of “hub neurons” that are preferentially recruited during memory retrieval.
- Rajasethupathy, P.*, Sankaran, S.*, Marshel, J.H.*, Kim, C.K., Ferenczi, E., Lee, S.Y., Berndt, A., Ramakrishnan, C., Jaffe, A., Lo, M., Liston, C. and Deisseroth, K., Projections from neocortex mediate top-down control of memory retrieval,Nature 526, pp. 653-659, 2015. (* indicates equal contributors) .
- Tomer, R., Lovett-Barron, M., Kauvar, I., Andalman ,A., Burns, V.M., Sankaran, S., Grosenick, L., Broxton, M., Yang, S., and Deisseroth, K. SPED light sheet microscopy: fast mapping of biological system structure and function, Cell, 163(1), pp. 1796-1806, 2015.